Vaginal and rectal GBS screening cultures at 35-37 weeks’ gestation for ALL pregnant women
(unless patient had GBS bacteriuria during the current pregnancy or a previous infant with invasive GBS disease)

Intrapartum prophylaxis indicated

• Previous infant with invasive GBS disease
• GBS bacteriuria during current pregnancy
• Positive GBS screening culture during current pregnancy (unless a planned cesarean delivery, in the absence of labor or amniotic membrane rupture, is performed)
• Unknown GBS status (culture not done, incomplete, or results unknown) and any of the following:
  • Delivery at <37 weeks’ gestation
  • Amniotic membrane rupture 18 hours
  • Intrapartum temperature 100.4°F ( 38.0°C)

Intrapartum prophylaxis not indicated

• Previous pregnancy with a positive GBS screening culture (unless a culture was also positive during the current pregnancy)
• Planned cesarean delivery performed in the absence of labor or membrane rupture (regardless of maternal GBS culture status)
• Negative vaginal and rectal GBS screening culture in late gestation during the current pregnancy, regardless of intrapartum risk factors

The recommendations for the prevention of neonatal Group B Strep disease are undergoing changes.  Recommendations in the United States may not match the recommendations in other countries.  Please review the guidelines appropiate for your country.